Title | Exploiting the conformational-selection mechanism to control the response kinetics of a smart DNA hydrogel |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Simon AJ, Walls-Smith LT, Plaxco KW |
Journal | Analyst |
Volume | 143 |
Pagination | 2531-2538 |
Abstract | The sequence-specific hybridization and molecular recognition properties of DNA support the construction of stimulus-responsive hydrogels with precisely controlled crosslink geometry. Here we show that{,} as predicted by the conformational selection mechanism{,} the response kinetics of such a hydrogel can be tuned over orders of magnitude by modulating the thermodynamic stability of its crosslinks. |
URL | http://dx.doi.org/10.1039/C8AN00337H |
DOI | 10.1039/C8AN00337H |