Exploiting the conformational-selection mechanism to control the response kinetics of a smart DNA hydrogel

TitleExploiting the conformational-selection mechanism to control the response kinetics of a smart DNA hydrogel
Publication TypeJournal Article
Year of Publication2018
AuthorsSimon AJ, Walls-Smith LT, Plaxco KW
JournalAnalyst
Volume143
Pagination2531-2538
Abstract

The sequence-specific hybridization and molecular recognition properties of DNA support the construction of stimulus-responsive hydrogels with precisely controlled crosslink geometry. Here we show that{,} as predicted by the conformational selection mechanism{,} the response kinetics of such a hydrogel can be tuned over orders of magnitude by modulating the thermodynamic stability of its crosslinks.

URLhttp://dx.doi.org/10.1039/C8AN00337H
DOI10.1039/C8AN00337H